This high performance version of the IS has it all.  Under the hood is a 5.0 liter V8 pushing  more than 400 HP to the rear wheels resulting in a 0-60mph of approximately 4.8 seconds.  The IS-F engine is mated to the world's first eight-speed direct sport-shift transmission. A new torque-converter lock-up control was developed that allows for a direct, crisp gear change through the constant lock-up of the torque converter in second through eighth gears. In Drive mode, the IS-F transmission performs with great smoothness, and the torque converter allows for great launch ability for fast standing-start acceleration that will register a zero-to-60 time in less than 4.9 seconds. This unique transmission also features an advanced Manual mode. A pair of paddles located within a fingertip's reach behind the steering wheel enables the driver to make ultra-fast up-shift gear changes within a tenth of a second. Downshifts are accompanied by automated and incredibly precise throttle blips to match engine RPM to vehicle speed.

To keep the speed in check, the IS-F features a modified suspension that is 1/2 inch. lower than the standard IS and features 19 inch BBS wheels wrapped in high performance tires.  Huge, 14.2-inch cross-drilled front discs are gripped by rigid, powerful six-piston aluminum calipers, while 13.6-inch rear cross-drilled discs feature two-piston calipers. High-friction brake pads are equipped on all four wheels. The brakes are finished with the Lexus name displayed on the calipers, a first for a Lexus production vehicle.